Acnotin 20 mg

Contains the active ingredient: Isotretinoin 20 mg

The exact mechanism of action of isotretinoin is not known. However, isotretinoin reduces sebaceous gland size and inhibits sebaceous gland activity, thereby decreasing sebum secretion. In addition, isotretinoin has been shown to have anti-keratinizing and anti-inflammatory actions. The exact role of these actions in clinical improvement of cystic acne is not known, especially with respect to prolonged remissions.


Rapidly absorbed from the gastrointestinal tract. Taking isotretinoin with food increases bioavailability relative to fasting conditions, probably as a result of easier absorption of this highly lipophilic medication.


Isotretinoin is metabolized in liver and possibly in the gut wall. The major identified metabolite in blood and urine is 4-oxo-isotretinoin, other identified metabolites are tretinoin and 4-oxo-tretinoin.


Isotretinoin appears to be eliminated almost exclusively by hepatic metabolism and biliary excretion.
Indications/Uses


Isotretinoin is a retinoid for systemic treatment of acne. It is indicated for severe forms of nodulo-cystic acne which are resistant to previous therapy, particularly cystic acne and acne conglobata, especially when the lesions involve the trunk.

Direction:

The therapy should be started with 0.5 to 1 mg/kg body weight daily with meals in 2 divided doses for 15-20 weeks.

The maximum dose is 2 mg/kg body weight daily. There should be an interval of at least 2 months before restarting treatment.

Size : 30 tablets/box